The province of Khost has 12 administrative units “Districts” where three areas named Matoon, Lakan and Shamal were also considered as administrative units.
 
Sabari:
The Sabari district is located 25 kilometers north of Khost city, which from south bordered with Janikhel district of Paktia province, from west with Musa Khel district of Khost, followed by Alisher Khel district from east. It borders with Khost city from south, where people are busy of various kinds of business.
 
Bak:
The Bak district is located 30 kilometers northeast of Khost city, which has shared border with Sabari and Zazi Maidan districts. A mega power dam is scheduled to be built in Bak district, which will produce electric power to whole province and bring many agricultural lands under irrigation.
 
Zazi Maidan:
The Zazi Maidan district is located 45 kilometers northeast of Khost city, which shared 81 kilometers border with Korma Agency of neighboring Pakistan. The residents of Zazi Maidan district were cooperating with Afghan government which is considered as secure town of the province, which mountains contained much chromites stones.
 
Alisher:
The Alisher district is located 35 kilometers east of Khost city on Duran Line, where large number of rice were cultivated, in addition to grow of other crops.
 
Gurbaz:
The Gurbaz district is located 20 kilometers southeast of Khost city, which shared long border with Miran Shah Area of northern Waziristan of Pakistan.  The residents of Gurbaz were busy of trade, who play active role in transportation of goods between Afghanistan and Pakistan.
 
Tani:
The Tani district is located 18 kilometres south of Khost city, which from west bordered with Naki district of Paktika province, from south it shared border with southern Waziristan of Pakistan. Its mountains contained large number of chromites and covered by trees.
 
Spira:
The Spira district is located 55 kilometres southwest of Khost city, which shared border with Naka, Zirok and Gayan districts of Paktika as well as located in joint border with southern Waziristan of Pakistan.
 
Domanda:
The Domanda district is located on Khost Gardiz highway east of Khost province, where mountains covered by trees and yield much pin-nuts crops.
 
Musakhel:
The Musakhel district is a mountainous which located 37 kilometres northeast of Khost city. Musakhel attached with Janikhel district of Paktia province, where mountins covered by trees, contained much chromites and yield pin-nuts walnuts and crops.
 
Qalander:
The Qalander district is located 40 lilometres east of Khost city, which from north bordered with Musa Khel district, with Nader Shahkot district is located in its south.
 
Nader Shahkot:
The Nader Shahkot district is located east of Khost city on Khost-Gardiz highway. Nader Shahkot district is a mountainous district, which mountains contained many trees of walnuts and pin-nuts. 
 
Ismail Khel (Mandozi):
The Ismail Khel (Mandozi) is located close to Khost city, which from south bordered with Tani district, with Nader Shahkot district is located in its east, where construction work on an airport is ongoing.